ArthroKnee: Interactive gonarthrosis data base for the three-dimensional microstructure, geometry, and biomechanics of the knee joint

Funding period: 1.10.15 - 30.09.17

Due to the increasing life expectancy the incidence of osteoarthritis (OA), the degeneration of articular cartilage and bone in the knee joint, is increasing worldwide. If all alternative treatment options are unsuccessful knee replacement surgery is inevitable. Concerning the annual number of knee replacement surgeries, Austria occupies an international leading position. Although the success rate of knee arthroplasties is high, complications like the loosening of the implant necessitate subsequent treatments. Moreover, the morphology and microstructure of the knee joint varies considerably between patients, therefore the anatomical expertise of orthopedic surgeons is essential. However, the clinical diagnosis is mainly based on radiological findings that neglect the three-dimensional architecture and microstructure of the knee joint.

In ArthroKnee we investigate OA degenerations in bone and cartilage samples using X-rays, micro-computed tomography (micro-CT) and phase contrast CT. Samples are collected from 100 OA patients undergoing a knee replacement surgery at the Klinikum Wels-Grieskirchen. By quantifying the statistical correlation between two-dimensional radiographies and three-dimensional micro-CT data patient-specific 3D models are generated on the basis of X-ray data. This study furthermore provides valuable information on the microstructure at the interface between bone and implant and represents the basis for the development of improved implant design and fixation concepts. Finally, finite element models based on Micro-CT data are created to investigate pathological effects of OA on knee joint mechanics, e.g. in relation to the interaction between bone microstructure and implant.

The results of ArthroKnee concerning OA microstructure, geometry and biomechanics are integrated in a software solution, including a database. This software offers a comparative data set for the radiographic evaluation of OA damage in new patients to support the clinical evaluation and treatment of OA. The software includes three-dimensional information of each data set hence representing an invaluable data source for the development of optimized implants, e.g. in terms of surface microstructural-properties and geometry.

Fig. 1 Sample geometry and microstructure in the proximal tibia (left). We focus on the quantification of microstructural parameters like mean trabecular thickness at the interface between implant and bone (middle). Examples for tibial and femoral implant designs (right).


  • FH OÖ Forschungs & Entwicklungs GmbH, AT (Coordinator)
  • Klinikum Wels-Grieskirchen
  • CDE - Communications-Data-Engineering GmbH
  • Dr. Pahr Ingenieurs e.U.


This project is funded by by the federal government of Upper Austria in the strategic program „Innovatives OÖ 2020“ (Aktionsfeld „Medizintechnik/Gesundheitswesen/alternde Gesellschaft)“. Further information can be found on

 InnoOOE2020 Programmlogologo looe


Dr. Sascha Senck
Project Coordinator
FH OÖ Forschungs- und Entwicklungs GmbH
Stelzhamerstraße 23, A-4600 Wels, AUSTRIA
Phone: +43 50804 44426
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
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